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pentobarbital will lessen the level or outcome of buprenorphine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.pentobarbital will lower the extent or effect of meloxicam by impacting hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Not known.Keep track of Intently (1)pentobarbital will decrease the e